开放期刊系统

FGFR3 突变尿路上皮癌术后快速复发 1 例报告

王 韶婧, 崔 吉丽, 崔 演

摘要

本文报道一例73岁男性左肾盂及输尿管高级别尿路上皮癌(pT3N0M0)患者,术后4个月即出现广泛转移。基因检测显示FGFR3 c.746C>G、TERT启动子突变,且PD-L1阴性(TPS<1%)、微卫星稳定(MSS)。一线吉西他滨联合顺铂化疗及替雷利珠单抗治疗失败,二线维迪西妥单抗初期获部分缓解,但最终因胆道梗阻死亡,总生存期13个月。本病例揭示了高危尿路上皮癌术后辅助治疗的必要性及PD-L1阴性/MSS患者免疫治疗耐药的临床挑战。

关键词

尿路上皮癌;FGFR3突变;快速复发;免疫治疗耐药

全文:

PDF

参考

[1]陶子豪,关豹,徐纯如,等. 2024 年上尿路尿路上皮癌诊治进展[J]. 泌尿外科杂志(电子 版),2025,17(1):55-61.

[2]卢智杰,李源. 抗体偶联药物联合免疫治疗用于上尿路尿路上皮癌的现状与挑战[J]. 中华外科 杂志,2024,62(8):737-743.

[3]中国临床肿瘤学会(CSCO). CSCO 尿路上皮癌诊疗指南(2024 年版)[J]. 中华肿瘤杂志,2024,46(3):201-210.

[4]Tse J,Ghandour R,Singla N,et al. Molecular Predictors of Complete Response Following Neoadjuvant Chemotherapy in Urothelial

Carcinoma of the Bladder and Upper Tracts. Int J Mol Sci. 2019;20(4):793. Published 2019 Feb 13.

[5]Li T,Hu W,Jin L,et al. Case Report:PD-L1-negative advanced b ladder cancer effective ly treated with an lot inib and t is le

lizumab:A report of two cases. Front Oncol. 2023;13:1164368. Pub lished 2023 Apr 14.

[6]Kato S,Goodman A,Wa lavalkar V,et al. Hyperprogressors afterImmunotherapy:Analysis of Genomic Alterations Associated with

Accelerated Growth Rate. Cl in Cancer Res. 2017;23(15):4242-4250.

[7]尹晓玉,路明,于泽芳,等. 新型抗体偶联药物——维迪西妥单抗[J]. 中国临床药理学与治疗 学,2024,29(11):1315-1320.

[8]淡墨,闻镍,刘丽,等. 甘草酸二铵通过上调 CYP3A4 拮抗雷公藤甲素诱导肝细胞毒性[J]. 中国新 药杂志,2015,24(12):

1349-1353,1357.

[9]Pezzicoli G,Cicir ie l lo F,Musci V,et al. Genomic Profi l ing and Molecu lar Character isation of Metastatic Urothe lial Carcinoma.

Medicina(Kaunas).2024;60(4):585. Pub lished 2024 Mar 31.

[10]Kunitoshi Chiba,Joshua Z Johnson,Jacob M Vogan,,et al.(2015)Cancer-associated TERT promoter mutations abrogate te

lomerase si lencing eLife 4:e07918.

[11]Wanna-Udom S,Aluksanasuwan S,Somsuan K,et al. ARID1A overexpression inhibits colorectal cancer ce ll migration through the

regulation of ep ithe lial- mesenchymal transition. Mol Med Rep. 2024;30(5):201.

[12]Jin J,Yang Q,Yu Y,et al. Comp lete response to t is le lizumab in a metastatic urothe lial carcinoma after surgery associated with

high tumor mutational burden:a case report. Anticancer Drugs. 2023;34(4):595-598.

作者简介:王韶婧(1997-8-),女,汉族,河南禹州人,硕士研究生,研究方向:抗肿瘤药物个体化治疗研究;

崔吉丽(2001-02-),女,汉族,江苏盐城人,硕士研究生,研究方向:抗肿瘤药物个体化治疗研究;

崔演(1972-),女,朝鲜族,吉林延吉人,博士导师,教授,主要研究方向:实体瘤的个体化治疗。


(0 摘要 Views, 0 PDF Downloads)

Refbacks

  • 当前没有refback。