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ADAMTS13 在各类疾病中的作用

陈 露阳, 金 圣宇

摘要

重度 ADAMTS13 缺乏(<10 iu/dL)可诊断为血栓性血小板减少性紫癜(TTP),并导致超大 vWF 多聚体积累、血小板聚集和广泛的微血栓,这可能危及生命。然而,ADAMTS13功能水平下降的临床意义不仅在 TTP 急性发作中很重要。在本综述中,我们讨论了低 ADAMTS13 活性对先天性和免疫介导的 TTP急性期和临床缓解时患者的影响。低ADAMTS13 活性对 TTP 以外的其他疾病领域的临床影响的证据正在被发现,在这里,我们探讨了低 ADAMTS13 活性对常见血栓性疾病的广泛影响

关键词

血栓性血小板减少性紫癜;血管性血友病因;临床影响

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参考

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通讯作者:金圣宇,男,1976.11.11,延边大学附属医院,血液内科主任,医学博士,出凝血方向。


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