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阿托西班联合硝苯地平及地屈孕酮在保胎治疗中的疗效分析

张 素素, 王 丽娟, 郭 乐, 张 继红

摘要

目的 探讨阿托西班联合硝苯地平及地屈孕酮治疗晚期先兆流产及先兆早产患者的临床疗效分析。方法 收集2021 年 1 月至 2023 年 1 月新余市妇幼保健院妇产科住院治疗的 80 例孕周在20-33周之间先兆流产或先兆早产的患者,对照组40 例患者予以硝苯地平及地屈孕酮治疗,研究组 40例患者予以阿托西班联合硝苯地平及地屈孕酮治疗,比较两组患者延长孕周2天和7天的有效率、孕周延长天数、妊娠结局、副作用发生率和围生儿结局。结果 研究组延长孕周2天和7天的有效率、延长孕周天数、妊娠结局满意率均高于对照组(P<0.05),研究组新生儿出生体重、1分钟Apgar评分、7天存活率均高于对照组(P<0.05)。结论 阿托西班联合硝苯地平及地屈孕酮能有效抑制宫缩,延长孕周,对提高新生儿生存率有积极作用。

关键词

阿托西班;硝苯地平;地屈孕酮;联合用药;保胎;疗效

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参考

[1]Ji Xiaohong,Wu Chengqian,Chen Min,et al. Analysis of risk factors related to extremely and very preterm birth:a retrospective

study[J]. BMC Pregnancy and Childbirth,2022,22(1):818-818.

[2]Wang Bing,Sun Jifei,Sun Yan,et al. A clinical analysis of very and extremely low birth weight preterm infants[J]. American journal

of translational research,2021,13(8):9395-9403.

[3]Fu S,Xie H,Zhong Y. et al. Atosiban Combined with Ritodrine for Late Threatened Abortion or Threatened Premature Labor Patients

with No Response to Ritodrine:A Clinical Trial[J]. Med Sci Monit. 2021,27:e929743-1-7.

[4]张蕊,张瑾. 紧急宫颈环扎术联合不同宫缩抑制剂的效果和安全性评价[J].中国实用妇科与产科杂志,2021,37(3):388-389

[5]Kuć,P,Laudański,P,Pierzyński,P,et al. The effect of combined tocolysis on in vitro uterine contractility in preterm labour[J].

Advances in Medical Sciences,2011,56(1):88-94.

[6]Kim SH,Riaposova L,Ahmed H,et al. Oxytocin Receptor Antagonists,Atosiban and Nolasiban,Inhibit Prostaglandin F2α-induced

Contractions and Inflammatory Responses in Human Myometrium[J]. Scientific reports,2019,9(1):5792.

[7]Schindler,Adolf E. Progestogens for treatment and prevention of pregnancy disorders[J]. Hormone molecular biology and clinical

investigation,2010,3(3):453-60.


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