开放期刊系统

难治性系统性红斑狼疮发病机制的研究进展与挑战

露 王

摘要

系统性红斑狼疮SLE是一种复杂的自身免疫性疾病,其中难治性亚型对常规治疗反应不佳,是临床管理的核心难题也是预后不良的主要原因。当前研究已经揭示了SLE涉及广泛的免疫失调,但对于其难治性的深层机制免疫学异常、遗传与表观遗传学改变、组织特异性损伤以及免疫代谢紊乱等这些方面认识仍不全面。深入阐明其独特发病机制是改善预后的关键。本文主要对最新研究进展进行系统综述,把现有的理论和发现整合起来,为深入理解难治性系统性红斑狼疮(R-SLE的病理本质、开发新型生物标志物及靶向治疗策略提供全面的理论依据。

关键词

难治性系统性红斑狼疮;发病机制;免疫失调;遗传易感性;表观遗传学;免疫代谢


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