牙周加速成骨正畸的免疫调节机制和作用
摘要
随时代发展,中国人对于口腔问题越发重视,错牙合畸形作为口腔三大疾病之一,发病率高达74%,越来越多的成人也开始寻求正畸,但成人因其生理特性,相较于儿童其正畸难度高,针对这些难点,现阶段已经研究出了许多加速牙齿移动的技术,其中PAOO(牙周加速成骨正畸)是应用比较广泛的一种。本综述将基于免疫微环境包括免疫细胞、免疫相关细胞因子和信号通路探究其在PAOO中选择性牙槽皮质骨切开术后期、正畸加力期和停止正畸加力后的稳定期中的成骨变化和作用。旨在阐明我们对PAOO成骨中免疫调节作用的理解和一些未知的问题。这样做的目的是利用已知的知识进一步修改现有的PAOO方法,并通过对我们所做的工作进行更详细的研究,在我们未知的领域开发新的PAOO策略。
关键词
参考
冯希平. 中国居民口腔健康状况——第四次中国口腔健康流行病学调查报告. 2018年中华口腔医学会第十八次口腔预防医学学术年会论文汇编, 2018: 14+13
厉松, 周洁珉, 任超超. 成人正畸治疗技术的发展与挑战. 华西口腔医学杂志, 2013, 31(06): 549~551
Keser E, Naini F B. Accelerated orthodontic tooth movement: surgical techniques and the regional acceleratory phenomenon. Maxillofac Plast Reconstr Surg, 2022, 44(1): 1
Vannala V, Katta A, Reddy M S, 等. Periodontal Accelerated Osteogenic Orthodontics Technique for Rapid Orthodontic Tooth Movement: A Systematic Review. J Pharm Bioallied Sci, 2019, 11(Suppl 2): S97~S106
Amit G, Jps K, Pankaj B, 等. Periodontally accelerated osteogenic orthodontics (PAOO) - a review. J Clin Exp Dent, 2012, 4(5): e292-296
Charavet C, Lambert F, Lecloux G, 等. [Accelerated orthodontic treatment using corticotomies: what are the minimally invasive alternatives?]. Orthod Fr, 2019, 90(1): 5~12
Wang S Y, Wang Z D, Yan B. [Advances in surgical techniques of periodontal corticotomy]. Hua Xi Kou Qiang Yi Xue Za Zhi, 2018, 36(2): 220~225
Veiseh O, Doloff J C, Ma M, 等. Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates. Nat Mater, 2015, 14(6): 643~651
Runyan C M, Gabrick K S. Biology of Bone Formation, Fracture Healing, and Distraction Osteogenesis. J Craniofac Surg, 2017, 28(5): 1380~1389
Cho T J, Kim J A, Chung C Y, 等. Expression and role of interleukin-6 in distraction osteogenesis. Calcif Tissue Int, 2007, 80(3): 192~200
Xiong Y, Mi B B, Lin Z, 等. The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity. Mil Med Res, 2022, 9(1): 65
Song L. Effects of Exercise or Mechanical Stimulation on Bone Development and Bone Repair. Stem Cells Int, 2022, 2022: 5372229
He Y, Gao Y, Ma Q, 等. Nanotopographical cues for regulation of macrophages and osteoclasts: emerging opportunities for osseointegration. J Nanobiotechnology, 2022, 20(1): 510
Caballero-Sánchez N, Alonso-Alonso S, Nagy L. Regenerative inflammation: when immune cells help to re-build tissues. FEBS J, 2022
Ando Y, Matsubara K, Ishikawa J, 等. Stem cell-conditioned medium accelerates distraction osteogenesis through multiple regenerative mechanisms. Bone, 2014, 61: 82~90
IL-6 is produced by adipose-derived stromal cells and promotes osteogenesis — Ewha Womans University.
杨崇实, 樊瑜波, 王超, 等. 皮质骨切开对牙槽骨改建影响的生物力学分析. 第十一届全国生物力学学术会议暨第十三届全国生物流变学学术会议会议论文摘要汇编, 2015: 269~270
Ozkan K, Eralp L, Kocaoglu M, 等. The effect of transforming growth factor beta1 (TGF-beta1) on the regenerate bone in distraction osteogenesis. Growth Factors, 2007, 25(2): 101~107
Lammens J, Liu Z, Aerssens J, 等. Distraction bone healing versus osteotomy healing: a comparative biochemical analysis. J Bone Miner Res, 1998, 13(2): 279~286
Ahmadi A, Mazloomnejad R, Kasravi M, 等. Recent advances on small molecules in osteogenic differentiation of stem cells and the underlying signaling pathways. Stem Cell Res Ther, 2022, 13(1): 518
Ransom R C, Carter A C, Salhotra A, 等. Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration. Nature, 2018, 563(7732): 514~521
Li Q, Xu R, Lei K, 等. Insights into skeletal stem cells. Bone Res, 2022, 10(1): 61
Yang Z, Wu B, Jia S, 等. The mechanically activated p38/MMP-2 signaling pathway promotes bone marrow mesenchymal stem cell migration in rats. Arch Oral Biol, 2017, 76: 55~60
Almalki S G, Agrawal D K. Effects of matrix metalloproteinases on the fate of mesenchymal stem cells. Stem Cell Res Ther, 2016, 7(1): 129
Son H E, Jang W G. Cip2A modulates osteogenic differentiation via the ERK-Runx2 pathway in MG63 cells. Biofactors, 2021, 47(4): 658~664
Yao H, Guo J, Zhu W, 等. Controlled Release of Bone Morphogenetic Protein-2 Augments the Coupling of Angiogenesis and Osteogenesis for Accelerating Mandibular Defect Repair. Pharmaceutics, 2022, 14(11): 2397
Hens J R, Wilson K M, Dann P, 等. TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro. J Bone Miner Res, 2005, 20(7): 1103~1113
Yu H C, Wu T C, Chen M R, 等. Mechanical stretching induces osteoprotegerin in differentiating C2C12 precursor cells through noncanonical Wnt pathways. J Bone Miner Res, 2010, 25(5): 1128~1137
Alzahrani M M, Makhdom A M, Rauch F, 等. Assessment of the effect of systemic delivery of sclerostin antibodies on Wnt signaling in distraction osteogenesis. J Bone Miner Metab, 2018, 36(4): 373~382
Percival C J, Richtsmeier J T. Angiogenesis and Intramembranous Osteogenesis. Dev Dyn, 2013, 242(8): 909~922
Ai-Aql Z S, Alagl A S, Graves D T, 等. Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis. J Dent Res, 2008, 87(2): 107~118
Moustakas A, Pardali K, Gaal A, 等. Mechanisms of TGF-beta signaling in regulation of cell growth and differentiation. Immunol Lett, 2002, 82(1~2): 85~91
Charoenpanich A, Wall M E, Tucker C J, 等. Microarray analysis of human adipose-derived stem cells in three-dimensional collagen culture: osteogenesis inhibits bone morphogenic protein and Wnt signaling pathways, and cyclic tensile strain causes upregulation of proinflammatory cytokine regulators and angiogenic factors. Tissue Eng Part A, 2011, 17(21~22): 2615~2627
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