人重组蛋白 C3AR1 在脓毒症中的含量变化
摘要
月至 2019 年 3 月重庆市第四人民医院重症科室收治的 17 名脓毒症患者和 20 名脓毒性休克患者的
临床资料，包括年龄、性别、体重等，根据患者在医院的情况分为脓毒症组和脓毒性休克组，同时
选取同期于本院体检人群中 10 例作为对照组。分别检测正常组、脓毒症组和脓毒性休克组患者血
中人重组蛋白 C3AR1 的表达量。对脓毒症组和脓毒性休克组利用序贯器官衰竭评分（Sequential
Organ Failure Assessment ，SOFA）和简化急性生理学评分（simplified acute physiology score 3，SAPS3）
进行测评。结果：经过 ELISA 试剂盒检测后，对正常组、脓毒症组和脓毒性休克组患者的年龄、性
别、体重及样本情况进行统计学分析。发现脓毒症组和脓毒性休克组的人重组蛋白 C3AR1 的表达
量都高于正常组，且脓毒性休克组的 C3AR1 的表达量远高于脓毒症组。脓毒性休克组的 SOFA 评
分和 SAPS3 评分都高于脓毒症组，说明脓毒性休克组的预后相比较差。结论：人重组蛋白 C3AR1
的表达量会随着脓毒症病情的严重程度而呈现出有规律的变化趋势，可以将人重组蛋白 C3AR1 认
定为脓毒症的标志性化合物。
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