开放期刊系统

慢性功能性便秘的多维度治疗策略

霍 倩, 邵 恒, 阮 庆蓉, 赵 敏君, 黄 红*

摘要

慢性功能性便秘(CFB)是一种普遍存在的消化系统疾病,给患者的生活质量带来了显著的负面影响。随着对
CFB 病因和机制的研究不断深入,临床治疗策略逐渐演变为多维度的综合管理模式。本文旨在综述慢性功能性便秘的主要
病因、临床表现以及多维度的治疗策略,包括饮食干预、药物治疗、非药物治疗等多种方法。通过对这些治疗手段的综合应用,
力求为临床提供更为有效的管理方案,以期改善患者的症状和整体生活质量。

关键词

慢性功能性便秘;多维度治疗;药物治疗;非药物治疗

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参考

[1]Shin JE, Park KS, Nam K. [Chronic Functional Constipa-

tion]. The Korean journal of gastroenterology = Taehan Sohwagi

Hakhoe chi. 2019;73(2):92-8.

[2]Barbara G, Barbaro MR, Marasco G, Cremon C. Chronic

constipation: from pathophysiology to management. Minerva gas-

troenterology. 2023;69(2):277-90.

[3]Lovell RM, Ford AC. Global prevalence of and risk factors

for irritable bowel syndrome: a meta-analysis. Clinical gastroen-

terology and hepatology : the official clinical practice journal of the

American Gastroenterological Association. 2012;10(7):712-21.e4.

[4]Naya N, Oka H, Hashimoto S, et al. Real-World Evidence

for the Safety and Effectiveness of Naldemedine in the Manage-

ment of Opioid-Induced Constipation in Patients With Cancer

Pain: Post-hoc Subgroup Analysis of Post-marketing Surveillance

in Japan. Cureus. 2023;15(9):e46090.

[5]Bassotti G, Gambaccini D, Bellini M. Velusetrag for the

treatment of chronic constipation. Expert opinion on investigation-

al drugs. 2016;25(8):985-90.

[6]Tack J, Camilleri M, Chang L, et al. Systematic review:

cardiovascular safety profile of 5-HT(4) agonists developed for

gastrointestinal disorders. Alimentary pharmacology & therapeu-

tics. 2012;35(7):745-67.

[7]Tsukanov VV, Rzhavicheva OS, Vasjutin AV, et al. [Ef-

ficacy of Kolofort for the treatment of patients with irritable bowel

syndrome]. Terapevticheskii arkhiv. 2016;88(8):40-5.

[8]Shang X, E FF, Guo KL, et al. Effectiveness and Safety of

Probiotics for Patients with Constipation-Predominant Irritable

Bowel Syndrome: A Systematic Review and Meta-Analysis of 10

Randomized Controlled Trials. Nutrients. 2022;14(12).

[9] 姚玉乔 , 徐龙剑 , 杨俊 , 等 . 基于肠道菌群结构特征

及 5-HT 探究枳术汤改善功能性便秘大鼠肠道传输功能的作

用机制 . 中国老年学杂志 . 2024;44(5):1206-9.

[10]Yoon JY, Cha JM, Oh JK, et al. Probiotics Ameliorate

Stool Consistency in Patients with Chronic Constipation: A Rand-

omized, Double-Blind, Placebo-Controlled Study. Digestive dis-

eases and sciences. 2018;63(10):2754-64.

[11]Liu L, Wang A, Shi H, et al. Efficacy and safety of pro-

biotics and synbiotics for functional constipation in children: A

systematic review and meta-analysis of randomized clinical trials.

Clinical nutrition (Edinburgh, Scotland). 2023;42(10):1817-26.

[12] 陈启仪 , 杨 波 , 田宏亮 , 等 . 菌群移植 3 932 例

治疗效果和并发症的 5 年随访分析 %J 中华消化杂志 .

2020;40(11):768-77.

[13]Wang L, Xu Y, Li L, et al. The impact of small in-

testinal bacterial overgrowth on the efficacy of fecal microbio-

ta transplantation in patients with chronic constipation. mBio.

2024;15(10):e0202324.

[14]Xiao-Ling Q, Gang C, Bo L, et al. Depression Is Asso-

ciated With Constipation in Patients With Parkinson’s Disease.

Frontiers in neurology. 2020;11:567574.

[15]Chiang CY, Lo SC, Beckstead JW, Yang CY. Associa-

tions between constipation risk and lifestyle, medication use, and

affective symptoms in patients with schizophrenia: a multicenter

cross-sectional study. Social psychiatry and psychiatric epidemi-

ology. 2024.

[16]Yang C, Hu T, Xue X, et al. Multi-omics analysis of

fecal microbiota transplantation’s impact on functional consti-

pation and comorbid depression and anxiety. BMC microbiology.

2023;23(1):389.

[17]Alborzi Avanaki F, Rafiee S, Aldin Varpaei H, et al. Bi-

ofeedback Treatment Can Improve Clinical Condition and Quality

of Life in Patients with Pelvic Floor Dyssynergy with Irritable

Bowel Syndrome: A Prospective Cohort Study. Middle East journal

of digestive diseases. 2023;15(1):45-52.

[18]Wang L, Liu R, Wang Y, et al. Effectiveness of a Bi-

ofeedback Intervention Targeting Mental and Physical Health

Among College Students Through Speech and Physiology as Bio-

markers Using Machine Learning: A Randomized Controlled Trial.

Applied psychophysiology and biofeedback. 2024;49(1):71-83.

[19]Özkütük N, Eşer İ, Bor S. Effectiveness of Biofeedback

Therapy on Quality of Life in Patients with Dyssynergic Defeca-

tion Disorder. The Turkish journal of gastroenterology : the official

journal of Turkish Society of Gastroenterology. 2021;32(1):22-9.

[20]Lazaridou A, Paschali M, Vilsmark ES, et al. Biofeed-

back EMG alternative therapy for chronic low back pain (the

BEAT-pain study). Digital health. 2023;9:20552076231154386.

[21]Schmidt K, Barac-Dammeyer D, Kowalski A, et al.

Implementing biofeedback treatment in a psychosomatic-psy-

chotherapeutic inpatient unit: a mixed methods evaluation of

acceptance, satisfaction, and feasibility. Frontiers in psychiatry.

2023;14:1140880.

[22] 支 宇 , 肖 莉 , 徐 鸿 , 等 慢性功能性便秘患者

高分辨率肛门直肠测压特征研究 . 中国老年保健医学 .

2020;18(1):20-2.

[23]Karthik N, Lodha M, Baksi A, et al. Effects of transcuta-

neous electrical nerve stimulation on recovery of gastrointestinal

motility after laparotomy: A randomized controlled trial. World

journal of surgery. 2024;48(7):1626-33.

[24]Kaut O, Janocha L, Weismüller TJ, Wüllner U. Trans-

cutaneous vagal nerve stimulation improves gastroenteric com-

plaints in Parkinson’s disease patients. NeuroRehabilitation.

2019;45(4):449-51.

[25]Yin J, Chen JD. Noninvasive electrical neuromodulation

for gastrointestinal motility disorders. Expert review of gastroen-

terology & hepatology. 2023;17(12):1221-32.

[26] 孙海涛 . 老年慢性功能性便秘采用中医综合治疗的

整体效果研究 . 智慧健康 . 2019;5(6):109-10,15.

[27]Chiaramonte R, Bonfiglio M, Caramma S, Condorelli R.

The Role of Rehabilitation in the Treatment of Constipation in

Oncological Patients. J Clin Med. 2023;12(15).

[28]Zhu D, Hu J, Chi Z, et al. Effectiveness and safety of

acupuncture in the treatment of chronic severe functional consti-

pation: A protocol for systematic review and meta-analysis. Medi-

cine. 2021;100(7):e24589.

[29]Wang H, Wang Q, Liang C, et al. Acupuncture improved

hepatic steatosis in HFD-induced NAFLD rats by regulating in-

testinal microbiota. Frontiers in microbiology. 2023;14:1131092.

[30]Doğan İ G, Gürşen C, Akbayrak T, et al. Abdominal

Massage in Functional Chronic Constipation: A Randomized Pla-

cebo-Controlled Trial. Physical therapy. 2022;102(7).

[31]Wang QS, Liu Y, Zou XN, et al. Evaluating the Efficacy

of Massage Intervention for the Treatment of Poststroke Consti-

pation: A Meta-Analysis. Evidence-based complementary and

alternative medicine : eCAM. 2020;2020:8934751.

[32]Sonu I, Oh SJ, Rao SSC. Capsules for the Diagnosis

and Treatment of Gastrointestinal Motility Disorders- A Game

Changer. Current gastroenterology reports. 2024;26(6):157-65.


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